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Author : Carl Deuker
ISBN : 0544649613
Genre :
File Size : 86. 23 MB
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From the author of "Gym Candy "comes a novel of football and bullying, finding friends and finding courage. With both good speed and good hands, wide receiver Brock Ripley should be a natural for the varsity team, but he shies away from physical contact. When he gets cut from varsity, he also loses his friendship with star quarterback Hunter Gates. Now a target for bullying, Brock struggles to overcome his fears and discover that, in his own way, he is brave enough."

The Gutless Wonder

Author : Tom Rooney
ISBN : 9781481739795
Genre : Biography & Autobiography
File Size : 35. 61 MB
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The Gutless Wonder is a true story of a young man faced with terrific pressures from secrets about his family. He kept this within himself and sought out the venue of playing high school football. His determination and will to never quit made it possible for him to achieve success under great physical and mental barriers that could not be understood by most everyone around him. His tragedies and accomplishments are detailed in the story and would give others a path to imitate if faced with similar situations.

Professor Trim S Becoming Gutless

Author : Garry Egger
ISBN : 9781741155198
Genre : Health & Fitness
File Size : 31. 79 MB
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Designed specifically for men, Becoming Gutless is a new and unique weight loss program which is being endorsed by doctors throughout Australia. 'Professor Trim's Medically Supervised Weight Loss Programs' were developed by well-known obesity and lifestyle expert Dr Garry Egger, originator of the hugely successful GutBuster program for men, and author of the bestselling GutBuster Waist Loss Program. Why should men worry about their weight? Just what is fat anyway? How do you know if you've got a weight problem? What works and what doesn't Becoming Gutless takes a unique approach to weight loss, and takes into consideration men's reluctance to this point to take responsibility for, and have an interest in, their increasing portulence. Full of practical advice about changing habits and increasing physical activity, it examines the low fat, low carbohydrate argument for weight-loss diets and comes up with an alternative solution - energy density. Similarly, Egger considers the controversy about the right type of exercise and concludes that the real issue is the volume of physical activity carried out - ie moving, not just exercising. Garry Egger is a Government advisor and a consultant for the World Health Organisation on weight control and an Adjunct Professor of Health Sciences at Deakin University. He is widely published throughout the media, although much of his time these days is spent educating medical practitioners throughout Australia, Asia and the Pacific on weight control and obesity management.

Development Of Gutless Adenoviral Vectors Encoding Anti Angiogenic Proteins For Therapy Of Prostate Cancer

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ISBN : OCLC:64441289
Genre :
File Size : 66. 2 MB
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The current work describes the development of technologies for long-term viral expression of soluble VEGF receptor anti-angiogenic proteins for therapeutic use in prostate cancer. Two technologies are described, "Gutless" adenoviruses and Adeno-associated viruses (AAV). Gutless adenoviruses have been reported to be capable of> 1 year transgene expression but their large-scale production is severely limited by helper virus and replication-competent adenovirus contamination. Several approaches for generation of pure gutless adenoviruses expressing the anti-angiogenic soluble Fik-1 VEGF receptor, towards achieving therapeutic responses which are more durable than conventional adenoviruses: (1) generation of a gutless adenoviral production method using 1-Scel-dependent packaging signal deletion and viral genome recombination to inactivate helper virus, (2) generation of complementation cell lines for gutless vectors using episomal or stable expression of helper genomes. Additionally, the use of adeno-associated viruses encoding either conventional soluble VEGF receptors or new variants with superior pharmacokinetic properties is described.

Gutless Protobranchia Bivalvia

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ISBN : OCLC:933053177
Genre :
File Size : 76. 44 MB
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Material accumulated by expeditions of the Institute of Oceanology of the USSR Academy of Sciences made it possible to broaden the knowledge of the Solemyida anatomy. Some of these organisms have been known from the end of the 19th century to have very weak development of the digestive tract combined with hypertrophied ctenidia. This paper describes the internal structure of 4 species of the Solemyida order: Petrasma atacama sp. nov., Acharax eremita sp. nov., Nucinella viridula sp. nov., and N. maxima (Thiele and Jaeckel).

Prostate Specific Gene Therapy Using A Gutless Adene Vector Expressing Antisense Tgf B And Psa Promoter Controlled Tnf A Gene

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ISBN : OCLC:946232075
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File Size : 45. 20 MB
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The goal of this research has been to develop an immune-based gene therapy that combines targeted cytotoxicity with reversal of local tumor immune suppression to eradicate prostate cancer cells. Reversal of local tumor immune suppression was achieved in vitro by blocking the over expression of TGF-beta2 produced by prostate cancer cells using TGF-beta2 phosphorothioate oligonucleotide antisense. We have been developing a gutless adenovector with extended transgene expression that we think will have enhanced safety for preclinical and clinical use. Our gutless adenovector DNA backbone contains the cytotoxic gene under the control of an improved prostate specific promoter and a marker OFP gene for detection in vivo studies. Our improved PSA promoter/enhancer presents 19-fold higher transcriptional activity compared to native PSA promoter/enhancer and has no loss of tissue specificity. Using Apo2L/TRAIL, a TNF-alpha related cytokine with less systemic toxicity, we have demonstrated selective cytotoxicity in our highly aggressive androgen-independent prostate cancer cell line (CL1). Further in vivo studies are being conducted to evaluate the overall efficacy and safety of Apo2L/TRAlL gene therapy in combination with TGF-beta2 antisense for prostate cancer treatment.

Gutless America

Author : William Dale Parker
ISBN : NWU:35556002090520
Genre : Social problems
File Size : 24. 53 MB
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